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吴丽娜博士研究生导师

个人简介

哈尔滨医科大学第四临床医学院纳米医学主任、研究员、博士研究生导师,国家卫健委分子探针与靶向诊疗重点实验室PI,中国抗癌协会纳米肿瘤专业委员会委员,中国核学会放射性药物分会理事,黑龙江省医师协会核医学专业委员会委员,黑龙江省医疗保健国际交流促进会数字医学专业委员会委员,黑龙江省中医药学会影像学分会委员。

研究领域

分子影像,分子探针设计与合成,新药开发。主持国家自然科学基金2项,国家留学基金2项,省部级课题10余项,参加国家重大科学研究计划1项。曾分别赴美国公立大学、私立大学和制药公司深造。在Molecular Cancer, Advanced Science, ACS Nano等期刊发表研究论文40余篇,单篇最高影响因子41,授权国家发明专利12项,国际专利2项。参编中、英文专著各1部。入选黑龙江省青年科技奖,哈尔滨医科大学十大杰出青年专家,哈尔滨医科大学医疗新技术一等奖,黑龙江省医疗卫生新技术应用奖I类推广项目等。作为主要参与人之一获得国家科技进步二等奖,黑龙江省医药卫生科学技术一等奖,黑龙江省科学技术二等奖等奖项。

既往成果

1)中央支持地方高校改革发展资金,经呼吸道递送靶向纳米探针肺癌精准诊疗研究,100万,优秀结题,主持

2)国家自然科学基金面上项目,基于1H/19F-MR的肺癌分子影像及其协同诊疗机制研究,55万,结题,主持

3)国家自然科学基金青年项目,MRI/CT双模式分子影像探针制备及其胶质瘤靶向成像研究,23万,结题,主持

4)哈尔滨医科大学少帅揭榜(杰出青年)项目,肺部重大疾病分子分型靶向探针关键技术研究,120万,在研,主持

4)国家重大科学研究计划,肺癌在体分子分型的新型纳米分子成像探针基础研究,2470万,结题,参与。

代表期刊

Nie C, A R, Wang J, Pan S, Zou R, Wang B, Xi S, Hong X, Zhou M, Wang H, Yu M, Wu L*, Sun X*, Yang W*. Controlled Release of Hydrogen-Carrying Perfluorocarbons for Ischemia Myocardium-Targeting 19 F MRI-Guided Reperfusion Injury Therapy. Advanced Science. 2023, 10, 2304178.

Wang H, Li X, Wang J, Wang JN, Zou H, Hu X, Yang L, Shen P, Rong A, Wang K, Li Y, Yang J, Wang K, Yang L, Wu L*, and Sun X*. Alveolar Macrophages-Mediated Translocation of Intratracheally Delivered Perfluorocarbon Nanoparticles to Achieve Lung Cancer 19F‑MR Imaging. Nano Letters, 2023; 23(7):2964–2973.

Li D, Yang J, Xu Z, Li Y, Sun Y, Wang Y, Zou H, Wang K, Yang L, Wu L*, Sun X*. c-Met-Targeting 19F MRI Nanoparticles with Ultralong Tumor Retention for Precisely Detecting Small or Ill-Defined Colorectal Liver Metastases. International Journal of Nanomedicine. 2023; 26(18):2181-2196.

Sun Y, Yang J, Li Y, Luo J, Sun J, Li D, Wang Y, Wang K, Yang L, Wu L*, Sun X*. Single low-dose INC280-loaded theranostic nanoparticles achieve multirooted delivery for MET-targeted primary and liver metastatic NSCLC. Molecular Cancer. 2022;21(1):212.

Yang J, Li Y, Sun J, Zou H, Sun Y, Luo J, Xie Q, Rong A, Wang H, Li X, Wang K, Yang L, Ma T, Wu L*, and Sun X*. An Osimertinib-Perfluorocarbon Nanoemulsion with Excellent Targeted Therapeutic Efficacy in Non-small Cell Lung Cancer: Achieving Intratracheal and Intravenous Administration. ACS Nano 2022, 16, 12590−12605.

Yingbo Li, Jie Yang, Guangying Gu, Xu Guo, Chunbo He, Jiemei Sun, Hongyan Zou, Hongbin Wang, Shuang Liu, Xiaona Li, Shujun Zhang, Kai Wang, Lili Yang, Ying Jiang, Lina Wu*, Xilin Sun*. Pulmonary Delivery of Theranostic Nanoclusters for Lung Cancer Ferroptosis with Enhanced Chemodynamic/Radiation Synergistic Therapy. Nano letters, 2022; 22(3):963–972.

Lina Wu, Hongyan Zou, Hongbin Wang, Sihang Zhang, Shuang Liu, Ying Jiang, Jing Chen, Yingbo Li, Mengping Shao, Ruixin Zhang, Xiaona Li, Jing Dong, Lili Yang, Kai Wang, Xinyuan Zhu, Xilin Sun*. Update on the Development of Molecular Imaging and Nanomedicine in China: Optical Imaging. WIREs Nanomedicine and Nanobiotechnology, 2020; 13(1): e1660

Lina Wu, Yujin Ji, Ding Dai, Ting Chen, Dashuai Yang, Yuanyue Liu, Zhijiang Wang*. Exceptional size-dependent activity enhancement in the catalytic electroreduction of N2 over Mo nanoparticles. International Journal of Hydrogen Energy. 2020, 45(56): 31841-31848.

Wu L, Liu F, Liu S, Xu X, Liu Z, Sun X*. Perfluorocarbons-Based F-19 Magnetic Resonance Imaging in Biomedicine. International Journal of Nanomedicine. 2020;15:7377-95.

Hongbin Wang#, Lina Wu#, and Xilin Sun*, Intratracheal Delivery of Nano- and Microparticles and Hyperpolarized Gases A Promising Strategy for the Imaging and Treatment of Respiratory Disease. Chest, 2020; 157(6):1579-1590.

Lina Wu#, Xiaofei Wen#, Xiance Wang, Chunan Wang, Xilin Sun, Kai Wang, Huiying Zhang, Todd Williams, Allen J. Stacy, Junjie Chen, Anne H. Schmieder, Gregory M. Lanza, Baozhong Shen*. Local Intratracheal Delivery of Perfluorocarbon Nanoparticles to Lung Cancer Demonstrated with Magnetic Resonance Multimodal Imaging. Theranostics, 2018;8(2):563-574.

Xiuan Xu, YulingYan, FangLiu, Lina Wu*, Mengping Shao, KaiWang, Xilin Sun, Yingbo Li, Ernest Sanyare Warmann Beinpuo, and Baozhong Shen*. Folate Receptor-Targeted 19F MR Molecular Imaging and Proliferation Evaluation of Lung Cancer. Journal of Magnetic Resonance Imaging, 2018; 48(6):1617-1625.

Xiuan Xu, Ruixin Zhang, Fang Liu, Jiaqi Ping, Hongbin Wang, Xiaofei Wen, Kai Wang, Xilin Sun, Hongyan Zou, Baozhong Shen*, Lina Wu*. 19F MR Imaging in Orthotopic Cancer Model via Intratracheal Administration of ανβ3-Targeted PFC Nanoparticles. Nanomedicine, 2018, 13(20):2551-2562.

Zhijiang Wang*, Kun Sun, Caiyun Liang, Lina Wu*, Zhuangzhuang Niu, and Jianmin Gao*. Synergistic Chemisorbing and Electronic Effects for Efficient CO2 Reduction using Cysteamine-functionalized Au Nanoparticles. ACS APPLIED ENERGY MATERIALS. 2019, 2(1): 192-195.

Kun Sun, Tao Cheng, Lina Wu, Yongfeng Hu, Jigang Zhou, Aimee Maclennan, Zhaohua Jiang, Yunzhi Gao, William A. III, Goddard, Zhijiang Wang. Ultrahigh Mass Activity for Carbon Dioxide Reduction Enabled by Gold-iron Core-shell Nanoparticles. Journal of the American Chemical Society, 2017, 139(44): 15608-15611.

Kun Sun#, Lina Wu#, Wu Qin, Jigang Zhou, Yongfeng Hu, Zhaohua Jiang, Baozhong Shen, Zhijiang Wang. Enhanced electrochemical reduction of CO2 to CO on Ag electrocatalysts with increased unoccupied density of state. Journal of Materials Chemistry A, 2016, 4, 12616.

Caiyun Liang#, Yongjie Gou#, Lina Wu#, Jigang Zhou, Zhiyu Kang, Baozhong Shen, and Zhijiang Wang. Nature of Electromagnetic-Transparent SiO2 Shell in Hybrid Nanostructure Enhancing Electromagnetic Attenuation. The Journal of Physical Chemistry C, 2016, 120, 12967-12973.

Huan Wang#, Lina Wu#, Jinfu Jiao, Jigang Zhou, Yongjun Xu, Hangyu Zhang, Zhaohua Jiang, Baozhong Shen and Zhijiang Wang. Covalent interaction enhanced electromagnetic wave absorption in SiC/Co hybrid nanowires. Journal of Materials Chemistry A, 2015, 3, 6517–6525.

Lina Wu#, Micah Luderer#, Xiaoxia Yang, Corban Swain, Huiying Zhang, Kate Nelson, Allen J Stacy, BaozhongShen*, Gregory M Lanza, and Dipanjan Pan*. Surface Passivation of Carbon Nanoparticles with Branched Macromolecules Influences near Infrared Bioimaging, Theranostics, 2013;3:677-686.

Lina Wu#, Xin Cai#, Kate Nelson, Wenxin Xing, Jun Xia, Ruiying Zhang, Allen J Stacy, Micah Luderer, Gregory M Lanza, Lihong V Wang*, BaozhongShen*, and Dipanjan Pan*. A Green Synthesis of Carbon Nanoparticles from Honey and Their Use in Real-Time Photoacoustic Imaging, Nano research, 2013, 6, 312-325.

Lina Wu#, Zhijiang Wang#, Baozhong Shen*. Large-scale Gold Nanoparticle Superlattice and its SERS Properties for the Quantitative Detection of Toxic Carbaryl. Nanoscale, 2013, 5, 5274-5278.

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