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刘大斌博士生导师

个人简介

哈尔滨医科大学附属第四医院教授,博士生导师。

哈尔滨医科大学海外高水平优秀青年人才

国家卫健委分子探针与靶向诊疗重点实验室PI

黑龙江省慢病管理学会肝病分委会副主任委员

中国抗癌协会肿瘤标志专业委员会青年创新联盟委员

中国抗癌协会肿瘤基因诊断专委会青年委员

BMC medicine 杂志associate editor

研究领域

研究主要集中在代谢性相关肝病的基础与转化应用领域。先后主持国自然面上项目、香港医学与健康研究基金、哈医大少帅揭榜项目各一项。

代表期刊

1 Lishuang Qi#, Yilong Tan#, Yunfei Zhou#, Yihong Dong#, Xun Yang, Shuyuan Chang, Lei Yu*, Dabin Liu*. Proteogenomic identification and analysis of KIF5B as a prognostic signature for hepatocellular carcinoma. Current gene therapy. Accept

2. Wang X#, Cui X#, Wang W#, Sun J, Wang Y, Han W, Xie X, Zhu Z, Zhang X, Yu L*, Liu D*. Deciphering essential druggable genes reveals potential immune-inflammatory axis in hepatocellular carcinoma. Comput Biol Med. 2023 Dec;167:107625.

3. Dabin Liu, Chi Chun Wong, Chuangen Li, Yunfei Zhou, Huarong Chen, Fenfen Ji, Minnie YY Go, Feixue Wang, Hao Su, Hong Wei, Zongwei Cai, Nathalie Wong, Vincent WS Wong, Jun Yu*. Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase 3 and is a Therapeutic Target. Gastroenterology 2021 Jun;160(7):2467-2482.e3.

4. Li C#, Wang Y#, Liu D, Wong CC, Coker OO, Zhang X, Liu C, Zhou Y, Liu Y, Kang W, To KF, Sung JJ, Yu J*. Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis. Gut. 2022 Nov;71(11):2253-2265.

5. Dabin Liu, Chi Chun Wong, Li Fu, Huarong Chen, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Yanquan Zhang, Weiqi Xu, Yidong Yang, Bin Wu, Gong Cheng, Paul Bo-San Lai, Nathalie Wong, Joseph JY Sung, Jun Yu*. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a direct pharmaceutical target. Science Translational Medicine 2018. Apr 18;10(437). 封面文章

6. Liu D#, Wang C#, Li C, Zhang X, Zhang B, Mi Z, An X, Tong Y*. Production and characterization of a humanized single-chain antibody against human integrin alphav beta3 protein. J Biol Chem. 2011 Jul 8;286(27):24500-7.6. Zhang B#, Liu D#, Bao Z, Chen B, Li C, Jiang H, Wang X, Mi Z, An X, Lu J, Tong Y*. High level soluble expression, one-step purification and characterization of HIV-1 p24 protein. Virol J. 2011 Jun 22;8:316.

7. Liu D#, Si B#, Li C, Mi Z, An X, Qin C, Liu W*, Tong Y*. Prokaryotic expression and purification of HA1 and HA2 polypeptides for serological analysis of the 2009 pandemic H1N1 influenza virus. J Virol Methods. 2011 Mar;172(1-2):16-21.

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