赵玉芳，哈尔滨医科大学医工交叉学院教授，主要从事生物医学工程学研究，重点关注组织微环境中细胞外基质动态演变机制与慢性疾病治疗、疾病组织微环境中的炎症调控策略等前沿研究方向。先后主持/参与国家重点研发计划、国家重大科技基础设施、全国重点实验室开放基金、前沿科学中心基础科研基金、国家自然科学基金青年项目等国家级/省部级项目11项，相关研究成果发表在Chemical Engineering Journal, Nature Communications，Oncogene等国际期刊，授权发明专利2 项。

教育经历

2014.03–2018.01        哈尔滨工业大学    生物医学工程      博士

2010.09–2013.07        东北农业大学       动物科学             硕士

2006.09–2010.07        东北农业大学       动物科学             学士

工作经历

2025.05–至今           哈尔滨医科大学     医工交叉学院                       特聘教授

2022.12–2025.05     哈尔滨工业大学     空间环境与物质科学研究院   副研究员

2018.07–2022.12     哈尔滨工业大学     空间基础科学研究中心          助理研究员

科研项目

1.国家重点研发计划“干细胞研究与器官修复”重点专项，特定环境条件下干细胞对心血管功能的重塑，2022.12-2027.12，2800万，参与。

2.国家重点研发计划“大科学装置前沿研究”重点专项，空间磁环境对生物节律的影响规律与机制研究，2022.12-2027.12，1800万，参与。

3.国家重大科技基础设施，空间环境地面模拟装置-空间生命科学研究装置，2015.09-2022.12，7249万，参与。

4.全国重点实验室开放基金，空间磁环境变化影响机体老化的机制规律及干预策略研究，2024.01-2025.12，35万，主持。

5.国家自然科学基金青年基金项目，基于模拟裸鼹鼠脑部微环境的炎症响应水凝胶的构建及其用于阿尔兹海默症治疗的研究，2020.01-2022.12，30万元，主持。

6.前沿科学中心基础科研基金，空间磁环境调控干细胞线粒体老化的机制研究，2023.01-2023.12，25万，主持。

7.哈尔滨工业大学科研创新基金，Gamma 节律低频磁场刺激对阿尔兹海默症小鼠影响的研究，2020.01-2021.12，10万，主持。

8.中国博士后科学基金面上项目，磁场用于阿尔兹海默病治疗的机制研究，2018.06-2020.06，5万，主持。

9.黑龙江省博士后资助项目，磁场效应对 Amyloid-β 纤维化调控作用的研究，2018.08-2020.08，5万，主持。

10.国家自然科学基金面上项目，裸鼹鼠高分子量透明质酸（ HMW-HA）与乳腺癌细胞相互作用研究体系的构建及其用于乳腺癌治疗的研究，2018.01-2021.12，61万，参与。

11.国家自然科学基金面上项目，可注射透明质酸水凝胶复合纳米粒子缓释系统用于小梁切除术后瘢痕化的研究，2018.01-2021.12，51万，参与。

代表性论文

1. Yufang Zhao#; Shupei Qiao#; Bosong Zhang; Yue Cao; Hui Tian; Runze Liu; Like Sun; Cao Wang; Liang Li; Ruiqi Wang; Yue Chen; Xiaolu Hou; Yongming Li; Jin Zhou; Liyi Li* and Weiming Tian*. A novel neuroinflammation-responsive hydrogel based on mimicking naked mole rat brain microenvironment retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease. Chemical Engineering Journal (2022): 133090.

2. Yufang Zhao#; Shupei Qiao#; Xiaolu Hou; Hui Tian; Shuai Deng; Kangruo Ye; Yongzhan Nie; Xiongbiao Chen; Hongji Yan; Weiming Tian*, Bioengineered tumor microenvironments with naked mole rats high-molecular-weight hyaluronan induces apoptosis in breast cancer cells, Oncogene, 38.22 (2019): 4297-4309.

3. Yufang Zhao#; Shupei Qiao#; Shuliang Shi; Lifen Yao; Xiaolu Hou; Chunfeng Li; Fenghuei Lin; Kai Guo; Alaka Acharya; Xiongbiao Chen; Yongzhan Nie; Weiming Tian* , Modulating three-dimensional microenvironment with hyaluronan of different molecular weights alters breast cancer cell invasion behavior, ACS applied materials & interfaces, 2017.2.27, 9(11) : 9327~9338.

4. Yufang Zhao#; Hongji Yan#; Shupei Qiao; Long Zhang; Tianran Wang; Qingyuan Meng; Xiongbiao Chen; Fenghuei Lin; Kai Guo; Chunfeng Li; Weiming Tian*, Hydrogels bearing bioengineered mimetic embryonic microenvironments for tumor reversion, Journal of Materials Chemistry B, 2016.8.19, 4(37): 6183~6191.

5. Bosong Zhang#; Yufang Zhao#; Kai Guo; Hui Tian; Cao Wang; Ruiqi Wang; Yue Chen; Xiongbiao Chen; Hongxia Zheng; Bingxin Gao; Jieyi Shen; Weiming Tian*; Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease, Bioengineering & Translational Medicine, 2022, e10459.

6. Shupei Qiao#; Yufang Zhao#; Chunfeng Li; Yanbin Yin; Qingyuan Meng; Fenghuei Lin; Yi Liu; Xiaolu Hou; Kai Guo; Xiongbiao Chen; Weiming Tian*, An alginate-based platform for cancer stem cell research, Acta Biomaterialia, 2016.4.19, 37(0) : 83~92.

7. Shupei Qiao#; Yufang Zhao#; Shuai Geng; Yong Li; Xiaolu Hou; Yi Liu; Fenghuei Lin; Lifen Yao; Weiming Tian*, A novel double-targeted nondrug delivery system for targeting cancer stem cells, International Journal of Nanomedicine, 2016.12.8, 11(0) : 6667~6678.

8. Cao Wang#; Shupei Qiao#; Yufang Zhao; Hui Tian; Wei Yan; Xiaolu Hou; Ruiqi Wang; Bosong Zhang; Chaofan Yang; Fuxing Zhu; Yanwen Jiao; Jiaming Jin; Yue Chen; Weiming Tian*; The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice, Nature Communications, 2023, 14(959).

9. Evgeny Kozhevnikov#, Shupei Qiao#, Fengtong Han, Wei Yan, Yufang Zhao, Xiaolu Hou, Alaka Acharya, Yijun Shen, Hui Tian, Haijiao Zhang, Xiongbiao Chen, Yuanchuan Zheng, Hongji Yan, Mian Guo, Weiming Tian*. A dual-transduction-integrated biosensing system to examine the 3D cell-culture for bone regeneration. Biosensors and Bioelectronics, 2019: 111481.

10. Juzhi Zhao#, Ruiqi Wang#, Jinyu Zhang#, Yufang Zhao, Shupei Qiao, Thomas Crouzier, Hongji Yan* and Weiming Tian*. A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance. Biofabrication 13.3 (2021): 035034.

11. Shupei Qiao#; Yi Liu#; Fengtong Han#; Mian Guo; Xiaolu Hou; Kangruo Ye; Shuai Deng; Yijun Shen; Yufang Zhao; Haiying Wei; Bing Song; Weiming Tian*, An intelligent neural stem cell delivery system for neurodegenerative diseases treatment, Advanced healthcare materials, 2018.5.2, 7(12).

12. Evgeny Kozhevnikov#; Xiaolu Hou; Shupei Qiao; Yufang Zhao; Chunfeng Li; Weiming Tian*, Electrical impedance spectroscopy-a potential method for the study and monitoring of a bone critical-size defect healing process treated with bone tissue engineering and regenerative medicine approaches, Journal of Materials Chemistry B, 2016.3.24, 4(16) : 2757~2767.

13. Weizhe Liu# ; Fang Han; Shuai Qu; Yuanfei Yao; Jianxiang Zhao; Muhammad Luqman Akhtar; Yanpeng Ci; Hao Zhang; Hongfei Li; Yufang Zhao; Lei Yue; Yao Zhang; Changlin Wang*; Yu Li *, MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development, Cell Death & Disease, 2018.9.24, 9(10).