姓 名：孙皓修

职称职务：讲师、博士生导师、硕士生导师

研究方向：肿瘤治疗性mRNA疫苗、肿瘤细胞生物学

E-mail：sunhaoxiu@hrbmu.edu.cn

孙皓修，理学博士，讲师，博士/硕士生导师。主要研究方向为肿瘤治疗性mRNA疫苗的构建和开发以及细胞稳态维持的分子机制，取得系列创新性成果。主要研究成果发表于Cell Death & Differentiation、Advanced Materials、Cancer Letters、Journal for Immunotherapy of Cancer、Lab on a Chip、BMC Medicine、Cell Proliferation等国际高水平生命科学杂志，参与多项国家级和省级科研项目。

教育经历

2016.09 – 2023.03 哈尔滨工业大学 生物医学工程  博士（导师：李钰教授）

2012.09 – 2016.06 东北农业大学 生物技术  学士

工作经历

2023.05 - 至今 哈尔滨医科大学 医工交叉学院 讲师

科研项目

国家自然科学基金委员会，青年科学基金项目，细胞稳态调控蛋白MARVELD1促进非整倍细胞染色体正确分离引发靶向治疗抵抗的机制研究（32400643），2025.01-2027.12，30万元，主持。

代表性论文

1. Haoxiu Sun^#, Chao Liu^#, Fang Han^#, Xiaoyu Lin, Liangyu Cao, Chenxing Liu, Qiuyu Ji, Jinjin Cui, Yuanfei Yao, Bojun Wang, Yuanyu liao, Huan Nie*, Yanqiao Zhang*, Yu Li*. The regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells [J]. Cell Death Differ, 2023 Apr;30(4):922-937. (SCI，IF: 12.067)

2. Rui Xue^#, Ye Tao*^#, Haoxiu Sun^#, Weiyu Liu, Zhenyou Ge, Tianyi Jiang, Hongyuan Jiang, Fang Han, Yu Li, Yukun Ren*. Small Universal Mechanical Module Driven by a Liquid Metal Droplet [J]. Lab Chip, 2021, 21(14): 2771-2780. (SCI，IF:7.517)

3. Zhenyou Ge,Wenshang Guo,Ye Tao*, Haoxiu Sun, Xiangyu Meng, Liangyu Cao, Shanguo Zhang, Weiyu Liu, Muhammad Luqman Akhtar, Yu Li*, Yukun Ren*. Wireless and Closed-Loop Smart Dressing for Exudate Management and On-Demand Treatment of Chronic Wounds. Adv Mater. 2023 Aug 7:e2304005. Epub ahead of print. (SCI，IF: 29.4)

4. Xiaolin Lu^#, Ruiqi Liu^#, Yuanyu Liao^#, Luying Cui^#, Haoxiu Sun, Dongzhi Zhang, Bojun Wang, Lin Fang, Xin Guan, Yuanfei Yao*, Chao Liu*, Yanqiao Zhang*. ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization. BMC Med. 2023 Sep 25;21(1):366. (SCI，IF=9.3)

5. Peng Dou, Yiqun Li, Haoxiu Sun, Wanqiu Xie, Xiaoqing Zhang, Xiaohan Zhang, Dandan Zhang, Shupei Qiao, Yanpeng Ci, Huan Nie, Fang Han*, Yu Li*. C1orf109l Binding Dhx9 Promotes DNA Damage Depended on the R-Loop Accumulation and Enhances Camptothecin Chemosensitivity [J]. Cell Prolif, 2020, 53(9): e12875. (SCI，IF: 8.755)

6. Chunbin Zhang^#, Fan Han^#, Ming Shi^#, Haoxiu Sun, Yiqun Li, Yanpeng Ci, Yuanfei Yao, Peng Dou, Muhammad Luqman Akhtar, Huan Nie, Jie He, Yu Li*. Marveld1 Interacting with Catalase Regulates Reactive Oxygen Species Metabolism and Mediates the Sensitivity to Chemotherapeutic Drugs in Epithelial Tumors of the Reproductive System [J]. Mol Carcinog, 2019, 58(8): 1410-1426. (SCI，IF: 5.139)

7. Ran Tang^#, Yiqun Li^#, Fang Han^#, Zhenzhi Li, Xiaoyu Lin, Haoxiu Sun, Xiaoqing Zhang, Qinghua Jiang, Huan Nie*, Yu Li*. A Ctcf-Binding Element and Histone Deacetylation Cooperatively Maintain Chromatin Loops, Linking to Long-Range Gene Regulation in Cancer Genomes [J]. Front Oncol, 2021, 11: 821495. (SCI，IF: 5.738)

8. Chao Liu^#, Ruiqi Liu^#, Bojun Wang^#, Jie Lian^#, Yang Yao, Haoxiu Sun, Chunhui Zhang, Lin Fang, Xin Guan, Jiaqi Shi, Shuling Han, Fei Zhan, Shengnan Luo, Yuanfei Yao*, Tongsen Zheng*, Yanqiao Zhang*. Blocking Il-17a Enhances Tumor Response to Anti-Pd-1 Immunotherapy in Microsatellite Stable Colorectal Cancer [J]. J Immunother Cancer, 2021, 9(1) (SCI，IF: 12.469)

9. Yang Yao^#, Chao Liu^#, Bojun Wang^#, Xin Guan^#, Lin Fang^#, Fei Zhan, Haoxiu Sun, Hengzhen Li, Changjie Lou, Feihu Yan, Xiaolin Lu, Luying Cui, Yuanyu Liao, Shuling Han, Yuanfei Yao*, Yanqiao Zhang*. Hoxb9 Blocks Cell Cycle Progression to Inhibit Pancreatic Cancer Cell Proliferation through the Dnmt1/Rbl2/C-Myc Axis [J]. Cancer Lett, 2022, 533: 215595. (SCI，IF: 9.756)

获奖情况

1. 哈尔滨工业大学优秀博士学位论文提名奖（2023.03）

2. 哈尔滨工业大学生命科学与技术学院优秀共产党员（2021.07）